Drugs Manufacturing and Packaging
Discover safer and more productive technical solutions for your drug production and preservation.
What is your key challenge in the production of medicines?
Get in touch with our team to discuss more about how our products and services can support you.
Designed for Your Manufactory Operations
Compliance
At each stage of your process, our solutions meet the strictest requirements in terms of specifications and compliance, e.g. European, American and Japanese pharmacopoeias.
Gas Expertise
Our engineering and instrumentation experts are well versed in various analysis techniques to help you with the calibration and validation of your analysis system.
Increase Yields
Nitrogen as a cryogenic liquid offers incomparable cold power and many advantages: improved flexibility and optimization of freeze-drying cycles, temperature control of chemical reactions, production of particles of uniform size in grinding, cryo-crystallization and micronization operations, etc.
Product Integrity and Quality
Our installation qualification services guarantee the quality of the gas up to the point of use. Our inerting, purging, pneumatic transfer and final packaging solutions under nitrogen eliminate oxygen and humidity around your products.
API pharmaceutical
Air Liquide offers gas solutions for the manufacture of API (Active Pharmaceutical Ingredients). Eliminate the uncertainty on the results related to the atmospheres, protect against unwanted reactions with Oxygen and moisture and guarantee that your installations meet the standards of your industrial sector, biopharmaceutical, food.
Cryogenic pelletising
Many scientific studies highlight the role of the gut microbiome in human health and the potential benefits of probiotics. Efficient pelletising of live microbial strains, such as probiotics, often requires very low temperatures. Air Liquide provides cryogenic solutions and tailored equipment to meet your needs.
Inerting, protective atmosphere and purification
Raw materials, API and excipients can be sensitive to Oxygen and moisture in the air. Therefore, they must often be protected with an inert gas to avoid unwelcome reactions, so that the active properties of the drug can be preserved. Inertisation, protection and purification with Nitrogen also contribute to reducing the risk of ignition and explosion when, for example, storing flammable solvents and milling powder. Air Liquide's solutions, which include gas, equipment and services, give you optimised Nitrogen consumption and precise control.
Reduction of particle size
Reducing the particle size of the API and excipients plays an important role in the properties and quality of the final product, i.e. solubility, uniform content and stability. Air Liquide offers a cryo-milling application where the material is cooled to low or very low temperatures with a cryogenic liquid, usually liquid Nitrogen, so that the particles have a dense size distribution.
Process Temperature Control
Certain steps in the manufacture of API, such as lyophilization and freeze drying, require low or very low temperatures. Liquid Nitrogen can be used to cool the process, either directly or indirectly as it is vaporised and heated.
Freeze drying is often the process of choice for stabilizing therapeutic proteins or vaccines. Cryogenic freezing is an environmentally friendly alternative to conventional refrigerants (CFCs) in freeze drying, as the production cycle can be reduced.
Pharmaceutical formulation, packaging and distribution
Air Liquide offers solutions that can help you protect sensitive products from exposure to Oxygen, optimise the composition of the drug, and maintain a cold chain for your clinical and biological samples. We design the gas installation by collaborating with you and ensure that your gas supply best suits your requirements and needs.
Logistics for the cold chain
Temperature variations can affect the stability of a medicine and thus its healing effect. Temperature-sensitive pharmaceutical and diagnostic products must be kept stable during distribution and arrive at their final destination without damage.
Air Liquide offers solutions that include cold chain logistics with dry ice or liquid Nitrogen. Even very sensitive deliveries of e.g. clinical samples, vaccines, diagnostic and biological equipment can be stored and transported without damage.
Packaging
Some medicines are sensitive to oxygen and moisture in the air. Therefore, they often have to be protected with an inert gas in order for them to maintain their healing effect. Some therapeutic proteins are packaged in a Nitrogen atmosphere during fill-finish operations to extend shelf life.
As the gas comes into direct contact with the final pharmaceutical product, it is important that the gas supply is reliable and complies with current regulations.
Waste water treatment
Our recommended gas solutions for your medicine production
Our experts will help you choose the right gas for your production and give you advice on the use of related equipment. In this way, it is possible to obtain reliable and high-quality of gas supply for your controlled atmospheres.
Why choose us
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Industry Leader
We are a global leader in gases, technologies and services for Industry and Health. -
Expertise
We have a global network of experts available to support you in developing solutions to meet your specifications and challenges. -
Extensive Infrastructure Network
We own and operate a number of production and filling facilities and more than 200km of pipeline networks that supply oxygen, nitrogen and hydrogen. -
Reliability
Our solutions are reliable, reproducible and in compliance with stringent and ever-evolving regulations. -
Focus on Quality
We strive for absolute quality control of processes and products, and our products meet and exceed industry standards. -
One-Stop Solution Provider
We provide a full range of products in various purities and supply modes and a spectrum of services to meet your specific needs. -
Sustainability
With a strong commitment to climate change and energy transition, our solutions are developed to achieve the highest performance in your applications while reducing your environmental impact.
Contact Us
Let our team answer your specific enquiry